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    • CIDIP 2020 (Alcoy)
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    • Proceedings from the International Congress on Project Management and Engineering
    • CIDIP 2020 (Alcoy)
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    Desarrollo de andamios mediante bioimpresión 3D con un potencial uso en Ingeniería de Tejidos

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    AT03-025_20.pdf (1.337Mb)
    Date
    2020
    Author
    Rubio-Valle, José Fernando
    Pérez-Puyana, Victor
    Jiménez-Rosado, Mercedes
    Rodríguez Ortíz, José Antonio
    Romero, Alberto
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    Abstract
    Tissue Engineering is defined as the science of design and manufacture of new tissues. It is a multidisciplinary field that requires the combination of biology (responsible for the technology of cultured cells together with growth factors), with materials engineering (whose purpose is the development of 3D structures called scaffolds) for their implementation in regenerative medicine. In this sense, in the present work a device formed by a polycaprolactone (PCL) support was developed on which a gelatin matrix (GE) is deposited and, finally, on the top, a collagen-based scaffold (C) is bioprinted together with a colony of cells. Once the device has been prepared at 22 °C, the gelatin matrix is discarded in an incubation stage at 37 °C, leaving the scaffold (C) deposited on the PCL support. Finally, the PCL-scaffold assembly is taken to a stage in a bioreactor to promote cell growth. This device is mechanically and microstructurally evaluated, together with cell viability studies, considered as one step further in its application in Tissue Engineering for the reconstruction of muscle tissue.
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    http://dspace.aeipro.com/xmlui/handle/123456789/2465
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